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Tirzepatide has three critical improvements over first-generation GLP1RAs
[9] For weight management, semaglutide (Wegovy) may be prescribed through specialist weight management services for eligible patients with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) and is typically prescribed for up to 2 years (NICE TA875)
They require dose escalation protocols to minimise side effects
Nesic, K., Parker, P., Swisher, E
FDA-Approved Medications Wegovy, Zepbound, Ozempic, and Mounjaro are specific finished products that have undergone extensive FDA review
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